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The research centres of the ISCIII undertake basic and applied research in public health through several priorities lines: emerging and re-emerging infectious diseases; the use of microorganisms in bioterrorism; tropical diseases; environmental strategies; rare diseases; telemedicine; bioinformatics; and neurodegenerative, heart and cancer-related diseases.

The Department of Scientific Research Coordination, manages and coordinates activity conducted at the ISCIII within the framework of calls for research projects.

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